Asian Journal of Research in Nursing and Health

Pain, which includes biological, psychological, social and spiritual factors, is a common symptom experienced by patients in intensive care.  Pain and stress represent two of the most pervasive clinical challenges encountered in nursing practice, yet their manifestation, interpretation, and management are profoundly shaped by the diversity of patient populations. Race and ethnicity, sex and gender, age, socioeconomic status, cultural background, and religious affiliation each exert demonstrable influences on how pain is perceived, expressed, communicated, and treated. Persistent disparities in pain management across diverse groups have been extensively documented in the clinical literature, with minority ethnic and lower socioeconomic populations consistently receiving less adequate analgesia than their White, higher-income counterparts. Stress, similarly, is both biologically mediated and socioculturally embedded; cumulative psychosocial adversity generates allostatic load with significant implications for long-term health. For nurses, who occupy the frontline of patient care and spend more time with patients than any other healthcare professional, navigating this diversity is not merely a technical challenge but an ethical imperative. Literature searches were conducted across the following databases: PubMed/MEDLINE, Web of Science, Scopus, Google Scholar, and the Cochrane Library as primary interdisciplinary sources, supplemented by CINAHL. The narrative review synthesises evidence from biomedical, psychological, anthropological, and nursing science literature to examine how diversity intersects with pain and stress management, and to derive implications for clinical nursing practice. Key themes include the biopsychosocial determinants of pain and stress variability; cultural and ethnic disparities in assessment and treatment; the role of implicit bias among healthcare providers; the cultural validity of standard assessment instruments; the evidence base for pharmacological and non-pharmacological interventions across diverse populations; and the implications for nursing education, workforce development, and institutional policy. The review concludes that culturally responsive, equitable, and person-centred nursing practice requires sustained educational investment, structural reform, and attentiveness to the intersectional nature of patient identity and experience.